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  • Writer's pictureDženita Omerkić Dautović, MSc

💊 All The Key Things You Need to Know About Lunsumio

Updated: Oct 29, 2023


What Is Lunsumio (Mosunetuzumab)?

Lunsumio (brand name) is a type of immunotherapy drug developed for treating certain types of cancer. It is an antibody-based therapy that targets a protein on the surface of many cancer cells. Lunsumio contains the active substance mosunetuzumab [citation].

For What Is Used Lunsumio (Mosunetuzumab)?

Lunsumio helps to stimulate the immune system to attack and destroy cancer cells. It is indicated for patients with relapsed or refractory follicular lymphoma after two or more lines of systemic therapy [citation; citation].

Certain types of B-cell lymphoma, such as follicular lymphoma (FL; the most common indolent non-Hodgkin’s lymphoma) [citation], chronic lymphocytic leukemia (CLL), or aggressive B-cell lymphoma, have a high probability of relapse or recurrence after being treated with rituximab. For this reason, Lunsumio has proven to be a promising solution for patients resistant to rituximab. Therefore, Lunsumio was approved in 2022 by the European Medicines Agency for treating patients with relapsed or refractory FL [citation; citation].

Lunsumio is currently in clinical development for treating various cancers, including acute myeloid leukemia (AML), multiple myeloma, and non-Hodgkin lymphoma. Unfortunately, the safety and efficacy of Lunsumio have not yet been established, and more research is needed to determine the best uses for this drug in cancer treatment [citation].


Who Developed Lunsumio (Mosunetuzumab)?

Lunsumio (mosunetuzumab) is being developed by Genentech (Roche) [citation; citation]. Genentech is a renowned biotechnology company committed to advancing the frontiers of medicine. With a rich history of groundbreaking discoveries, Genentech is at the forefront of developing innovative therapies to tackle some of the world's most challenging diseases.

Genentech is famous for its pioneering work in the biotechnology field, particularly in developing innovative therapies for severe medical conditions. They are widely recognized for their groundbreaking contributions to cancer, immunology, neuroscience, and rare diseases.


What Is the Mechanism of Action for Lunsumio (Mosunetuzumab)?

Lunsumio, mosunetuzumab, is a bispecific monoclonal antibody intended for binding to:

  1. CD20, a protein found on B-lymphocytes, including cancer cells,

  2. and CD3, a protein on T-cells (another type of white blood cell) [citation; citation].

In this way, the drug specifically joins to cancer cells and T cells, redirecting them to eliminate malignant B cells [citation]. T-cells are part of the body's defense and help protect the body from infection, but they can also destroy cancer cells by their cytotoxic activity [citation].


What Are the Key Advantages of Lunsumio (Mosunetuzumab)?

The key advantages of Lunsumio as an immunotherapy drug for the treatment of cancer are:

  1. Targeted Approach: Lunsumio specifically targets CD20 and CD3 simultaneously to redirect T cells for cytotoxic activity on cancer cells.

  2. Well-tolerated: Potential of being effective in patients with unfavorable features with a tolerable rate and severity of cytokine release syndrome, immune effector cell-associated neurotoxicity, and infectious complications. Clinical trials to date have shown that Lunsumio is well-tolerated and has a manageable side effect profile. [citation].

  3. Potential for Improved Outcomes: In the main trial, 80% and 60% of subjects responded positively to the objective response to the drug's effectiveness [citation].

  4. Mosunetuzumab has the potential to bypass rituximab resistance in patients with follicular lymphoma [citation].

Note: These advantages are based on preclinical and early-stage clinical data, and further research is needed to fully establish the benefits of Lunsumio in cancer treatment. Although this drug is approved, it is still classified as an investigational drug, in the context of combination with other drugs, used for additional purposes and broad treatment in patients. Suspected side effects are also monitored and evaluated [citation].


What Are the Key Side Effects of Lunsumio (Mosunetuzumab)?

The critical side effects of Lunsumio that have been observed in clinical trials include:

  1. Cytokine release syndrome (CRS), including life-threatening reactions (corticosteroids, antipyretics, and antihistamines are taken to avoid this phenomenon)

  2. Severe infections have also been recorded, including pneumonia, bacteremia, and sepsis or septic shock.

  3. Tumor flare and tumor lysis syndrome [citation].



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