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  • Writer's pictureDr Edin Hamzić

What is PIK3CA H1047R?

The H1047R is one of two main hotspots for activating mutations in the PIK3CA oncogene, which lies within the kinase domain of the PIK3CA protein. H1047R mutation hotspot cause:

  1. Increased phosphorylation of Akt and Mek 1/2

  2. Growth factor-independent cell survival and transformation in cell culture [citation]

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